Research field

• • In vitro characterization of new molecular biomarkers of pathology.
  • Identification and functional characterization of specific microRNAs as tumor biomarkers for diagnosis, prognosis or therapeutic tools, in breast and prostate cancer.
  • Identification of microRNAs as circulating biomarkers of temporal lobe epilepsy (TLE).
  • Identification and functional characterization of microRNAs of cardiac hypertrophy.

CV

National collaboration

• • University of Milan;
  • San Raffaele Hospital (HSR);
  • Department of Biotechnologies of HSR (DiBiT-HSR);
  • ICS Maugeri-Pavia;

International collaboration

• • Karolinska Institute, Sweden;
  • European Synchrotron Radiation Facility (ESRF)-Grenoble

Recent Bibliography

Cava C*, Novello C*, Martelli C, Lodico A, Ottobrini L, Piccotti F, Truffi M, Corsi F, Bertoli G#, Castiglioni I. Theranostic application of miR-429 in HER2+ breast cancer. Theranostics 2020; 10(1):50-61. doi:10.7150/thno.36274.

Colaprico A, Olsen C, Bailey MH, Odom GJ, Terkelsen T, Silva TC, Olsen AV, Cantini L, Zinovyev A, Barillot E, Noushmehr H, Bertoli G, Castiglioni I, Cava C, Bontempi G, Chen XS, Papaleo E. Interpreting pathways to discover cancer driver genes with Moonlight. Nat Commun. 2020 Jan 3;11(1):69. doi:10.1038/s41467-019-13803-0.

Cantini L*, Bertoli G*, Cava C, Dubois T, Zinovyev A, Caselle M, Castiglioni I,  Barillot E, Martignetti L. Identification of microRNA clusters cooperatively acting on epithelial to mesenchymal transition in triple negative breast cancer.  Nucleic Acids Res. 2019 Mar 18;47(5):2205-2215. doi: 10.1093/nar/gkz016.

Gallivanone F, Cava C, Corsi F, Bertoli G#, Castiglioni I. In Silico Approach for the Definition of radiomiRNomic Signatures for Breast Cancer Differential Diagnosis. Int J Mol Sci. 2019 Nov 20;20(23). pii: E5825. doi: 10.3390/ijms20235825.

Cava C, Manna I, Gambardella A, Bertoli G#, Castiglioni I. Potential Role of miRNAs as Theranostic Biomarkers of Epilepsy. Mol Ther Nucleic Acids. 2018 Dec 7;13:275-290. doi: 10.1016/j.omtn.2018.09.008.

Cava C*, Bertoli G*, Castiglioni I. In silico identification of drug target pathways in breast cancer subtypes using pathway cross-talk inhibition. J Transl Med. 2018 Jun 5;16(1):154. doi: 10.1186/s12967-018-1535-2.

Cava C*, Bertoli G*, Colaprico A, Bontempi G, Mauri G, Castiglioni I. In-Silico  Integration Approach to Identify a Key miRNA Regulating a Gene Network in Aggressive Prostate Cancer. Int J Mol Sci. 2018 Mar 19;19(3). pii: E910. doi:10.3390/ijms19030910.

Cava C*, Bertoli G*, Colaprico A, Olsen C, Bontempi G, Castiglioni I. Integration of multiple networks and pathways identifies cancer driver genes in pan-cancer analysis. BMC Genomics. 2018 Jan 6;19(1):25. doi:10.1186/s12864-017-4423-x.

Bertoli G#, Cava C, Diceglie C, Martelli C, Rizzo G, Piccotti F, Ottobrini L, Castiglioni I. MicroRNA-567 dysregulation contributes to carcinogenesis of breast cancer, targeting tumor cell proliferation, and migration. Breast Cancer Res Treat. 2017 Feb;161(3):605-616. doi: 10.1007/s10549-016-4079-2.

Bertoli G, Cava C, Castiglioni I. MicroRNAs as Biomarkers for Diagnosis, Prognosis and Theranostics in Prostate Cancer. Int J Mol Sci. 2016 Mar 22;17(3):421. doi: 10.3390/ijms17030421.