Temi di Ricerca

Tecniche di imaging cardiaco non invasivo Positron Emission Tomography (PET) e Cardiac Magnetic Resonance (CMR).

Disfunzione del microcircolo coronarico e sue conseguenze nell’ipertrofia ventricolare primitiva e secondaria.

Ischemia miocardica, compromissione del microcircolo e disfunzione ventricolare sinistra.

Quantificazione e caratterizzazione funzionale della placca aterosclerotica con traccianti PET.

CV

Collaborazioni Nazionali

Università Vita Salute San Raffaele, Milano

Dipartimento di Cardiologia ASST Grande Ospedale Metropolitano Niguarda, Milano

Collaborazioni Internazionali

Prof. Shimokawa Tohoku University Sendai Japan

Prof. S. Neubauer Oxford University United Kingdom (studio HCMR sulla cardiomiopatia ipertrofica)

Prof. C. Kramer University of Virginia Charlottesville (VA) USA (studio HCMR sulla cardiomiopatia ipertrofica)

Prof. M. DiCarli Dott. S. Dorbala Brigham and Women’s Hospital Harvard Medical School, Boston (MA) USA

Bibliografia recente di maggior rilevanza 

Rimoldi O, Maranta F. Microvascular dysfunction in infiltrative cardiomyopathies. J Nucl Cardiol. 2019;26:200-207

Neubauer S, Kolm P, Ho CY, Kwong RY, Desai MY, Dolman SF, Appelbaum E, Desvigne-Nickens P, DiMarco JP, Friedrich MG, Geller N, Harper AR, Jarolim P, Jerosch-Herold M, Kim DY, Maron MS, Schulz-Menger J, Piechnik SK, Thomson K, Zhang C, Watkins H, Weintraub WS, Kramer CM on behalf of HCMr investigators. Distinct subgroups in hypertrophic cardiomyopathy in the nhlbi hcm registry. J Am Coll Cardiol. 2019;74:2333-2345

Ammirati E, Moroni F, Magnoni M, Rocca MA, Anzalone N, Cacciaguerra L, Di Terlizzi S, Villa C, Sizzano F, Palini A, Scotti I, Besana F, Spagnolo P, Rimoldi OE, Chiesa R, Falini A, Filippi M, Camici PG. Progression of brain white matter hyperintensities in asymptomatic patients with carotid atherosclerotic plaques and no indication for revascularization. Atherosclerosis. 2019;287:171-178

Pedrotti P, Vittori C, Facchetti R, Pedretti S, Dellegrottaglie S, Milazzo A, Frigerio M, Cipriani M, Giannattasio C, Roghi A, Rimoldi O. Prognostic impact of late gadolinium enhancement in the risk stratification of heart transplant patients. Eur Heart J Cardiovasc Imaging. 2017;18:130-137

Gupta A, Taqueti VR, van de Hoef TP, Bajaj NS, Bravo PE, Murthy VL, Osborne MT, Seidelmann SB, Vita T, Bibbo CF, Harrington M, Hainer J, Rimoldi O, Dorbala S, Bhatt DL, Blankstein R, Camici PG, Di Carli MF. Integrated noninvasive physiological assessment of coronary circulatory function and impact on cardiovascular mortality in patients with stable coronary artery disease. Circulation. 2017;136:2325-2336

Camici PG, d’Amati G, Rimoldi O. Coronary microvascular dysfunction: Mechanisms and functional assessment. Nat Rev Cardiol. 2015;12:48-62

Murthy VL, Naya M, Taqueti VR, Foster CR, Gaber M, Hainer J, Dorbala S, Blankstein R, Rimoldi O, Camici PG, Di Carli MF. Effects of sex on coronary microvascular dysfunction and cardiac outcomes. Circulation. 2014;129:2518-2527

Recio-Mayoral A, Rimoldi OE, Camici PG, Kaski JC. Inflammation and microvascular dysfunction in cardiac syndrome x patients without conventional risk factors for coronary artery disease. JACC Cardiovasc Imaging. 2013;6:660-667

Bolli R, Tang XL, Sanganalmath SK, Rimoldi O, Mosna F, Abdel-Latif A, Jneid H, Rota M, Leri A, Kajstura J. Intracoronary delivery of autologous cardiac stem cells improves cardiac function in a porcine model of chronic ischemic cardiomyopathy. Circulation. 2013;128:122-131

Rimoldi O. Assessing the activity of cardiac sympathetic innervation with a novel pet tracer. Eur J Nucl Med Mol Imaging. 2012;39:1901-1903

Gaemperli O, Shalhoub J, Owen DR, Lamare F, Johansson S, Fouladi N, Davies AH, Rimoldi OE, Camici PG. Imaging intraplaque inflammation in carotid atherosclerosis with 11c-pk11195 positron emission tomography/computed tomography. Eur Heart J. 2012;33:1902-1910

Arnold JR, Karamitsos TD, Bhamra-Ariza P, Francis JM, Searle N, Robson MD, Howells RK, Choudhury RP, Rimoldi OE, Camici PG, Banning AP, Neubauer S, Jerosch-Herold M, Selvanayagam JB. Myocardial oxygenation in coronary artery disease: Insights from blood oxygen level-dependent magnetic resonance imaging at 3 tesla. J Am Coll Cardiol. 2012;59:1954-1964

Lamare F, Hinz R, Gaemperli O, Pugliese F, Mason JC, Spinks T, Camici PG, Rimoldi OE. Detection and quantification of large-vessel inflammation with 11c-(r)-pk11195 pet/ct. J Nucl Med. 2011;52:33-39